These results suggest that social isolation of juvenile rats decreases CRF-R1 in Nac terminals. Results: Interestingly, the effect of a CRF-R1 antagonist upon DA and glutamate levels in juvenile no isolated rats is occluded when rats are isolated. The CRF system is composed by CRF, urocortins, CRF-R1 and CRF-R2 receptors. The CRF system mediates part of the brain stress response. Next, we evaluated eventual changes in corticotropin-releasing factor (CRF) system function induced by isolation. Interestingly, preliminary results showed no difference between DA extracellular levels in the Nac shell of young adult isolated and no isolated rats. Prolonged social isolation of juvenile rats (10 days) increases DA extracellular level in the Nac shell. Methods: We performed in vivo microdialysis to evaluate neuronal changes induced by isolation. We are interested in evaluating neuronal changes induced by isolation that could explain the difference between the expression on anxiety like behavior in juvenile and young adult rats. ![]() Interestingly, rats isolated during their juvenile stage developed an increase in anxiety-like behavior, but rats isolated during their young adult stage showed no effects upon anxiety-like behavior (Arakawa, 2003). Juvenile rats exposed to social isolation showed increased anxiety-like behavior and significant changes in Nucleus Accumbens (Nac) dopamine (DA) activity in adulthood (Lukkes et al. It is well known that early life adversity may lead to the development of psychiatric disorders in adulthood. Pontificia Universidad Catolica de Chile, Santiago, Chileīackground: Social isolation is a model of chronic stress widely used to study early life adversity.
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